Speaker
Description
Mathematical models and cost-effectiveness analyses have been playing a major role when UK policymakers consider changes in the UK national vaccination programmes. As an example, I would like to introduce my mathematical modelling work on paediatric pertussis vaccination programmes in the UK. Pertussis, also known as whooping cough, had been a leading cause of childhood morbidity and mortality until a pertussis vaccine programme introduction in 1957 in the UK. The pertussis incidences had increased with lowered vaccine coverage after the fear of a potential relationship between whole-cell pertussis vaccine and brain damage in the late 70s and early 80s. The coverage had been recovered and remained high since the 90s. However, there was a resurgence of pertussis cases among infants who were too young to be vaccinated in 2012. We developed a mathematical model of the pertussis transmission dynamics and historical pertussis vaccination programmes in the UK to investigate potential causes of the 2012 resurgence and the potential impact of additional pertussis vaccination programmes in the UK. I would like to introduce findings from this mathematical modelling study, and its impact on the UK and WHO recommendations.
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