Speaker
Description
MPI (Magnetic Particle Imaging) is a new medical imaging technology that uses the characteristics of superparamagnetic nanomagnetic particles to image the location information of a specific disease in a three-dimensional space to find the presence and location of disease. After Gleich and Weizencker published a paper on the basic theory and applications of MPI in 2005, many studies have published various techniques for MPI [1]. Our research team created a mechanical FFL motion-based MPI system to obtain images of mouse-sized samples [2,3]. The generation of FFL (Field Free Line) is basically based on the permanent magnet array, and the acquisition and processing of the signal is based on FMMD. This time, our research team developed an MPI device with a 100mm clear aperture by greatly improving the FOV. To realize a clear aperture up to 100 mm, the size and weight of the FFL generation unit increased significantly. In the existing MPI system, the mechanical axis of rotation of the FFL was perpendicular to the ground, but in the new system, it was implemented horizontally to the ground to mechanically move the high-load FFL. The sample to be measured was implemented in a structure inserted from the bottom to the top. Our research team's MPI system generates FFLs based on permanent magnets and mechanically moves the FFLs so that it can be manufactured and operated at a very low cost in power and cooling systems, which is considered to be able to contribute to the development of MPI. And by implementing the system with a clear aperture of 100mm, it showed the potential of MPI equipment to be applied to the human body.
References
[1] B. Gleich and J. Weizenecker, “Tomographic imaging using the nonlinear response of magnetic particles,” Nature, vol. 435, no. 7046, Art. no. 7046, Jun. 2005, doi: 10.1038/nature03808.
[2] S.-M. Choi et al., “A novel three-dimensional magnetic particle imaging system based on the frequency mixing for the point-of-care diagnostics,” Scientific Reports, vol. 10, no. 1, 2020, doi: 10.1038/s41598-020-68864-9.
[3] H. Hong, J. Jong, T. Kim, and B. Seo, “MPI system using the mechanically movement of a three-dimensionally arranged permanent magnets,” International Journal on Magnetic Particle Imaging, vol. 8, no. 1 Suppl 1, Art. no. 1 Suppl 1, Mar. 2022, doi: 10.18416/IJMPI.2022.2203031.
| Keywords | MPI, MNPs, FMMD |
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