Speaker
Description
Over the past two decades, circulating biomarkers (CBs) including circulating tumor cells (CTCs), exosomes, ctDNA and etc. have been widely recognized for their importance in clinical trials. Recent advances in microfluidic approaches have made it possible to enrich CTCs and form circulating tumor cell (CTC)–neutrophil clusters which are highly potent precursors of cancer metastasis. Our novel microfluidic platform for exploring CTC–neutrophil clusters can therefore play a promising role in cancer-metastasis studies. In addition, exosomes are recognized as promising biomarkers for several diseases. Thus, a simple, low-cost, and rapid microfluidic platform has been extensively developed to meet the requirement in biomedical applications. Herein, I highlight several microfluidic-based enrichment methods that are the subject of considerable research interest and suggest a microfluidic-based analysis platform for the down-stream analysis of CBs. We also discuss critical concerns and future directions for research including rapid and selective isolation of CTCs and exosomes.
References
1) Microfluidic recapitulation of circulating tumor cell–neutrophil clusters via double spiral channel-induced deterministic encapsulation Junhyun Park, Sunyoung Park, Kyung-A Hyun, and Hyo-Il Jung Lap on a Chip (HOT Articles) 18,3483-3497, (2021)
2) Microfluidic chip for rapid and selective isolation of tumor-derived extracellular vesicles for early diagnosis and metastatic risk evaluation of breast cancer Hogyeong Gwak, Sunyoung Park, Junmoo Kim, Jeong Dong Lee, In-Soo Kim, Seung-Il Kim, Kyung-A Hyun, Hyo-Il Jung* Biosensors and Bioelectronics, 192, 113495, (2021)
| Keywords | Circulating biomarkers, Microfluidic device, In vitro diagnostics, |
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