Speaker
Description
Abstracts
Around the world, the incidence of cancer is increasing every year. The surgery, radiotherapy, and chemotherapy currently being treated in hospitals are not perfect and cause a lot of pain to patients. In addition, the patient's quality of life is reduced due to side effects or sequelae after treatment. In comparison, photodynamic cancer treatment using lasers is effective for various types of cancer, but there are limitations in treating cancers that occur deep in the human body. Therefore, as a way to overcome this problem, cancer treatment method using nanoparticles capable of self-lighting have been developed and are approaching commercialization.
The principle of nanoparticle self-lighting photodynamic therapy (SLPDT) is that after the nanoparticle photosensitizer reagent is carried out intravenously or directly to the site of the malignant tumor, there is a time for accumulation in the body for 30 minutes to 1 hour. During this time, in normal cells, the reagent is extinguished and expelled by metabolic processes, and specifically, it accumulates in a group of heterologous cells of the affected area (cancer tissue, inflammatory cells, fungal bacteria, cells infected with foreign pathogens, etc.). After administration of the reagent, radioisotopes are administered intravenously or directly to the affected area of the malignant tumor, and all therapeutic procedures are completed simply.
The reagents (self-lighting nanoparticles) accumulated in the abnormal tissue are converted into PPIX (activators) that react with the energy of light. PPIX, which is specific only for abnormal cells (malignant tumors), is excited by the ionization energy produced by radioactive isotopes. In addition, it has a mechanism to produce toxic substances (singlet oxygen) and free radicals through various processes and necrosis only abnormal cells.
Nanoparticle self-lighting photodynamic therapy (SLPDT) for cancer treatment using photodynamic therapy has the advantage of minimizing side effects and toxicity to the whole body compared to radiotherapy or chemotherapy. And regardless of the size of the total dose administered, the same site can be treated repeatedly.
References
[1] HS.Lim, “Reduction of thermal damage in photodynamic therapy by laser irradiation
techniques” Journal of Biomedical optics, Vol.17, N0.12,2012
[2] H. S. Lim, “Development and optimization of a diode laser for photodynamic therapy,”
Int. J. Laser Ther. 20(3), 195–203 (2011).
[3] G. Lan, K. Ni, W. Lin, Nanoscale metal–organicframeworks for phototherapy of
cancer," Coord.Chem. Rev. 379, 65–81 (2017)
| Keywords | photodynamic therapy, cancer, new modality, nanoparticle, self-lighting, radioisotopes(99 mTc), intraoperative,PPIX (activator),singlet oxygen, photosensitizers, |
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