Speaker
Chirlmin Joo
(Delft University of Technology)
Description
Single-molecule fluorescence studies reveal valuable structural and functional information on biomolecules. However, conventional single-molecule methods have limited sequence diversity due to time, effort and cost constraints. To overcome this, we combine surface-based single-molecule fluorescence with next generation sequencing, enabling massively parallel single-molecule experiments for millions of sequences. Our technique provides sequence-dependent biophysical and biochemical properties at the single molecule level, advancing our understanding of molecular structures and functions and enabling more accurate models in biomolecular engineering.
References
Severins et al, in preparation
| Keywords | single-molecule biophysics |
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Primary author
Chirlmin Joo
(Delft University of Technology)
