Speaker
Description
Malfunction of the skeletal muscle cells cause a wide range of problems such as developmental disorders, congenitor myopathies or dystrophies, traumatic muscle injury, and even sarcopenia. Furthermore, the importance of exercise biology is catching increasing attention in this ever-ageing demographics. While these underscore the pressing need to better understand the biology of skeletal muscles cells, these cells remain notoriously difficult to study owing to their unique syncytial structure. My recent work characterized single-nucleus transcriptomics of myofibers in homeostatic and disease conditions, which provided new insights into how the inner working of muscle cells are organized and go awry in disease. In addition, I will also present new works carried out in my own lab that aims to develop new tools to further dissect the role of nuclear heterogeneity in muscle cells.
References
https://www.nature.com/articles/s41467-020-20064-9
| Keywords | Skeletal muscle, myopathy, dystrophy, ageing, differentiation |
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